Dr. Majed Ahmed. M. Al-Shaeri., MSc, PhD.

Associate Professor of Environmental Toxicology

Director of Environmental Protection & Sustainability Laboratory (EPS).

Director of Toxicology Research Group.

Head of the Electron Microscopy Unit.

 Secretary of the Departmental Board – Biological Sciences Department

King Abdulaziz University

Building 90A, Third floor, Room 36C57.

Saudi Arabia P.O. Box 80203 Jeddah 21589.

Phone: +966(0)126400000 (office) 64742 (lab) 52291.

Mobile: +966(0) 556372123.

Fax: +966(0)126400000 (64702).

E-mail: malshaere@kau.edu.sa

Current Research Interest

 Dr. Majed is an Associate Professor of Environmental Toxicology in the Department of Biological Sciences at King Abdulaziz University. Dr. Al-Shaeri received an MSc (2011) and PhD (2014) in (Toxicology & Nano-Ecotoxicology) from Heriot-Watt University in Edinburgh, Scotland, United Kingdom. Dr. Al-Shaeri is interested in environmental toxicology, nanobiotechnology, nanotoxicity, and the synthesis and characterization of nanomaterial (NMs). Current research efforts are focused on toxicology & eco-nanotoxicology. Recent research activity has focused on (1) the eco/toxicity of nanomaterials, (2) the safety of nanomaterials in medicine, (3) dietary exposure to metal nanoparticles and other contaminants, (4) body systems nanotoxicology (immunotoxicity; gastro-intestinal physiology and pathology; neurotoxicity) and (5) the impact of nanoparticles on the genomics and proteomics of microorganisms (Bacteria and microalgae). Other research efforts are focused on the different manufacturers of making NMs use a variety of synthesis methods, employing different also catalytic metals and carbon sources leading to raw CNTs of varying purities and length, two characteristics important in determine the behaviour of CNTs and their potential health risk following exposure. The Fundamental studies currently underway involve nanomaterial interactions other substances, and their potential toxicity and behaviour and how they may effect on biological systems, including in vitro and in vivo studies, intracellular fate; uptake, translocation and distribution. The understanding of NMs functionalization, synthesis, characterization, behaviour and interaction with metals provides good evidence that may lead to an understanding of their fate and effect on environment and human health. The research premise will aid in novel nanobiotechnology and nanotoxicology model development and thus enable safe implementation of nanomaterial products.

Keyword: Nanobiotechnology, ecotoxicology, nano-physiochemical properties, DNA damage, cytotoxicity, genotoxicity, nanoparticles fate, metals interaction, drug delivery, human health and Environmental issues.

Academic Education

Additional Certificates

• 2011-2014 Four Excellence Rewards and an Appreciation Letter For academic excellence during my MSc & PhD studies from Royal Embassy of Saudi Arabia, Cultural Bureau, London, United Kingdom.
• 2014 Certificate of attendance “the 3D Imaging Technology Workshop” organized by Zeiss microscopy, IMCES imaging center, Essen, Germany.
• 2013 Certificate of attendance the continuing education course “Advances in Nanotoxicology – Challenges” organized by Society of Toxicology 52^nd Annual meeting in San Antonio, Texas, US.
• 2012 Certificate of attendance the workshop entitled “ Opportunities and Challenge for Faculty Members Today ” organized by the Academic leadership Center, Ministry of Higher Education, Saudi Arabia held in London, United Kingdom.
• 2010 Certificate of attendance the training of “Negotiation and influencing skills” organized by Quality Side Training Ltd in the UK.

Dr Al-Shaeri’s Laboratory Facilities & Research Experience

EPS provides aquatic, terrestrial and marine ecotoxicology testing to evaluate the environmental safety of human and animal health products.

• Marine laboratory & Aquarium.

• Nanoparticles (NPs) & nanomaterials (NMs) surface modification and bio-functionalization.
• Determination the synthesis and characterization of NPs and NMs.
• Electronic microscopes (SEM&TEM).
• Fluorescence and laser confocal microscopy.
• Characteristic organic and non-organic particles using Raman spectroscopy
• Determination the size agglomeration and surface charge of NPs & NMs using dynamic light scattering (DLS) and zeta potential.
• Examining the Physiochemical properties of NPs & NMs and their interactions with other substances in Environment.
• Detection residual metals impurities (RMI): Atomic absorption spectrometer & inductively coupled plasma mass spectrometry (ICP-MS).
• Cytotoxicity assays using Trypan blue and Flow cytometry.
• Genotoxicity assay using comet assay.
• Tissues and cells staining.
• Proteins extraction and analysis (SDS-PAGE).
• DNA extraction and analysis by gel electrophoresis.
• Biochemical and Cytological assay (ROS, TUNEL, COMET, etc.).
• Histology practices: preparation of paraffin embedded samples for histological analysis.

Highlights of Professional (Scientific) collaborations & Community services

• 2020 Consultant in expertise house for integrated control and environmental health.
• 2019 Advisor in cultural relations office, vice president for development, king Abdulaziz University.
• 2018 Advisor in Zad Investment Company for Environmental Management.

• 2015 Participant with International scientific research collaborators.

• 2012 Symposium organizer- Postgraduate students’ conference, Edinburgh, United Kingdom.
• 2008 Conference organizer International conference on Nanotechnology: Opportunities and Challenges at King Abdulaziz University, SA.

Conferences, seminars, and Workshops

• 2019 Opportunities for Freshwater Aquaculture in mainland KSA (Ministry of Environment Water and Agriculture in cooperation with Saudi Aquaculture Society) 1 May, Alfaredah Hall, Faris Section – Riyadh, SA.
• 2019 Development of Aquaculture courses workshop at the Faculty of Marine Sciences (National Fisheries Development Program in cooperation with the Saudi Aquaculture Society), Jeddah, SA.

• 2018 The Kingdom of Saudi Arabia’s R&D International Collaboration Conference, Riyadh, SA.
• 2016 International Conference on the Marine Environment of the Red Sea (ICMERS) 14 -16 November at KAUST, SA.
• 2014 Conference chair and local host of 11th International Congress on the Biology of Fish (American Fisheries Society, Physiology Section) 3-7 August at Heriot-Watt, UK.
• 2014 SETAC Europe Annual Meeting in Basel, Switzerland.
• 2014 The 3D Imaging Technology Workshop” organized by Zeiss microscopy, IMCES imaging center, Essen, Germany.
• 2013 SOT’s ⁵²nd Annual Meeting, at the Henry Gonzalez Convention Center San Antonio, USA.
• 2013 Marine Alliance for Science and Technology for Scotland (MASTS) in Edinburgh, UK.
• 2013 ²³rd SETAC Europe Annual Meeting in Glasgow, UK.
• 2012 Marine Alliance for Science and Technology for Scotland (MASTS) in Edinburgh, UK
• 2011 Sixth International Conference on the Environmental Effects of Nanoparticles and Nanomaterials in London, UK.
• 2010 International Conference sponsored by Al-Imam Muhammad Ibn Saud Islamic University and hosted by The University of Manchester, UK.
• 2010 international conference on Nanotoxicology at Napier Edinburgh University, UK.
• 2008 International conference on Nanotechnology: Opportunities and Challenges, SA.
• 2007 Sixth conferences for medical education at King Abdulaziz University, SA.
• 2005 Saudi International conferences for blood diseases and babyhood oncology, Jeddah, SA.

Memberships in Learned Societies

• • 2021 Fellow, Royal Society of Biology, London, UK.
  • 2021 Member, Academic Accreditation Committee, Department of Biological Sciences at KAU, SA.
  • 2019 Member, Central Laboratories Committee at King Abdulaziz University, SA.
  • 2016 Member, Graduate Studies Committee at King Abdulaziz University, SA.
  • 2013 Member, Comet Assay Interest Group, England, UK.
  • 2012 Member, Society of Environmental Toxicology and Chemistry (SETAC), Brussels, Belgium.
  • 2011 Member, Society of Toxicology, Reston, Virginia, USA.
  • 2011 Member, Nanotoxicology specialty section, USA.
  • 2011 Member, Marine Alliance for Science and Technology for Scotland, Scottish Oceans Institute, East Sands, St Andrews, Scotland, UK.
  • 2010 Member, Nano-safety Research group, School of life Sciences, Heriot Watt University, UK.
  • 2008 Member, Electron microscope unit, and Nano-bio unit, Department of Biological Science, King Abdulaziz University, SA.
  • 2007 Member, Committee of Nano- Bio research, king Saud University, SA.
  • 2005 Member, Saudi Association for Environmental Sciences at King Abdulaziz University, SA.

  Student Supervision

  BSc level

  2021

• Ameen Alsaggaf
• Ibrahem Alharbi

  Project: Antibacterial activity of Ferula asafetida extract against certain human pathogenic bacteria.

  2022

• Ammar Dagriri
• Basil Kutbi
• Mohammed Melebari

  Project: Antibacterial activity of Coleus forskohlii extracts against pathogenic bacteria.

   

  MSc level

• Raneem Al-amri (Completed 2021) - Fish biological responses to silver nanoparticles (Co-Supervisor).
• Wedad Hakami (Completed 2021) - Investigation of effect of anti-diabetic drug on weight gain induced by anti-psychotic drug.
• Amer Aljohani (Completed 2020) - Growth performance and composition of muscle of tilapia and shrimp by replacement of fishmeal with cattle leather meal.
• Shyma Al Qarni (Completed 2020) - Mitigation of cadmium toxicity on seed germination of tomato (solanum lycopersicum L.) by single-walled carbon nanotubes (Co-Supervisor).
• Sabreen Behairy (Completed 2019) - Functionalized single-walled carbon nanotubes as drug delivery for breast cancer treatment.

• 2012 Member, Society of Environmental Toxicology and Chemistry (SETAC), Brussels,Current PhD Students - 2022:

• ·         Saleh Al maaqar (co-supervisor with Prof Bassam Aljohani)

  Project: Synthesized green nanoparticles for treating bacterial meningitis.

   

  ·         Ahmed alshater 

  Project: Functionalized nanoparticles as a drug delivery for treating bacterial meningitis             

Editorial board membership and reviewing

• Member, Editorial Board, PLOS ONE Journal, US.
• Member, Editorial Board, MC Pharmaceutical Sciences Journal, India.
• Regular reviewer for a number of journals11

Citation Indices

h-index: 12

ResearchGate Citations: 468

RG Score: 22.16

Reads: 6,097

Research Interest Score: 345.8

Book Chapters Published

Bilal Ahmed, Mohammad Saghir Khan, Quaiser Saquib, Majed Al-Shaeri, Javed Musarrat. (2018) Interplay Between Engineered Nanomaterials (ENMs) and Edible Plants: A Current Perspective: In book entitled “Nano Phytotoxicity” Eds; Faisal, M. et al. published by the Springer International Publishing AG, part of Springer Nature 2018. doi.org/10.1007/978-3-319-76708-6; ISBN 978-3-319-76707-9;  ISBN 978-3-319-76708-6 (eBook).

List of Peer-Reviewed Publications

1. 1. Al-Shaeri, M., Stobie, M., Cyphus, P., Paterson, L. & M G J Hartl. (Submitted) Trophic transfer of single-walled carbon nanotubes at the base of the food chain and toxicological response. Ecotoxicology and Environmental Safety. (IF: 6.3).
   2. Karthika C, Najda A, Klepacka J, Zehravi M, Akter R, Akhtar MF, Saleem A, Al-Shaeri M, Mondal B, Ashraf GM, Tagde P. (2022) "Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach". Molecules. Jan;27(14):4663. (IF: 4.4).
   3. Mollik, Murshida, Md Rahman, Majed Al-Shaeri, Ghulam Md Ashraf, Athanasios Alexiou, and Md Gafur. (2022) "Isolation, characterization and in vitro antioxidant activity screening of pure compound from black pepper (Piper nigrum)." Environmental Science and Pollution Research: 1-13. (IF: 4.2).
   4. Al-Maaqar, Saleh M., Bassam O. Al-Johny, Fahad D. Al-Sharif, Majed Al-Shaeri, Naser AL-Kenani, and Muhammad Barkaat Hussain. (2022) "Sensitivity of multidrug-resistant pathogenic bacteria to ethanolic extract of Ziziphus spina-christi L. (Sidr) leaves". Bioscience Research. 2 19(3): 1467-1475. (IF: 0.7).
   5. SA Al-amri, Raneem, Yasser M Saad, Majed Al-Shaeri, and Ahmed Atef. (2021) "Pterophyllum scalare Genome Responses to Silver Nanoparticles." Egyptian Journal of Aquatic Biology and Fisheries 25, no. 1: 965-982. (IF: 0.78).
   6. Alkenani, N.A., Basabreen, M.A., Shaala, L.A., Alshaeri, M.A., Mahyoub, J.A., Ullah, I., Algamdi, K.M. and Youssef, D.T., (2021) "Larvicidal Effects of Carbon Nanotubes Loaded with Selected Marine 'Sponges' Extracts". Archive of Pharmacy Practice. 12- 2021 Issue 3.
   7. Reyad, N. F., Al-Ghamdi, H. A., Abdel-Raheem, M. A., & Al-Shaeri, M. A. (2020). The effects of botanical oils on the red palm weevil, Rhynchophorus ferrugineus Olivier (Coleoptera: Curculionidae). Appl. Ecol. Environ. Res, 2909-2919. (IF: 0.71).
   8. Anwar, Yasir, Ihsan Ullah, M. A. Alsheri, and Bassam Oudh AlJohny (2020). "Ex-situ synthesis of bacterial cellulose-copper oxide nanoparticles for effective chemical and biological properties." Desalin. Water Treat 197: 182-190. (IF: 0.854).
   9. Alsaedi, Faris Bakheet, Ihsan Ullah, Majed Al-Shaeri, Rashad R. Al-Hindi, and Khalid MS Al-Ghamdi. (2020) "Abasyn Journal of Life Sciences Open Access." Sciences 3, no. 1: 24-30. (IF: 2.078).
   10. 10.Shah, Zarbad, Sara Hassan, Kausar Shaheen, Shahid Ali Khan, Taj Gul, Yasir Anwar, Majed Al-Shaeri et al. (2020) "Synthesis of AgNPs coated with secondary metabolites of Acacia nilotica: An efficient antimicrobial and detoxification agent for environmental toxic organic pollutants." Materials Science and Engineering: C :110829. (IF: 7.328).
   11. 11.Ali, Khursheed, Quaiser Saquib, Bilal Ahmed, Maqsood A. Siddiqui, Javed Ahmad, Majed Al-Shaeri, Abdulaziz A. Al-Khedhairy, and Javed Musarrat. (2020) "Bio-functionalized CuO nanoparticles induced apoptotic activities in human breast carcinoma cells and toxicity against Aspergillus flavus: An In vitro approach." Process Biochemistry. (IF: 2.952).
   12. Majed A. Al-Shaeri (2019) Antimicrobial Activity of Single-Walled Carbon Nanotubes (SWCNTs) Against Marine Bacteria Staphylococcus aureus. Acta Scientific Pharmaceutical Sciences.                       
   13. Sabir, Jamal SM, Abdelfatteh El Omri, Babajan Banaganapalli, Majed A. Al-Shaeri, Naser A. Alkenani, Mumdooh J. Sabir, Nahid H. Hajrah et al. (2019) "Dissecting The Role of Nf-Kb Protein Family and its Regulators in Rheumatoid Arthritis Using Weighted Gene Co-Expression Network." Frontiers in Genetics 10: 1163. (IF: 4.151). 
   14. Zarith Asyikin Abdul Aziz, Hasmida Mohd Nasir, Akil Ahmadb, Siti Hamidah Mohd Setapara, Hafandi Ahmad, Mohd Hezmee Mohd Noor, Mohd Rafatullah, Asma Khatoon, Mohd Adnan Kausar, Irfan Ahmad, Shahida Khani, Majed Al-Shaeri, Ghulam Md. Ashraf (2019). Enrichment of Eucalyptus oil nanoemulsion by micellar nanotechnology: transdermal analgesic activity using hot plate test in rats’ assay. Scientific reports. (IF: 4.525).
   15. Majed Al-Shaeri and Shakeel Ahmed Ansari (2019) Overviewing the application of galactosidase “Immobilized on Nanoparticles” in dairy industries. Brazilian Archives of Biology and Technology. (IF: 0.5).                               
   16. Tijo Cherian, Khursheed Ali, Saher Fatima, Quaiser Saquib, Sabiha M Ansari, Hend A Alwathnani, Abdulaziz A Al-Khedhairy, Majed Al-Shaeri, and Javed Musarrat (2019). Myristica fragrans bio-active esters functionalized ZnO nanoparticles exhibit antibacterial and antibiofilm activities in clinical isolates. Journal of Microbiological Methods. (IF: 1.803).                       
   17. Ansari, Shakeel A., and Majed Al-Shaeri. (2019) "Biotechnological application of surface modified cerium oxide nanoparticles." Brazilian Journal of Chemical Engineering 36, no. 1: 109-115. (IF: 1.5).
   18. Majed Al-Shaeri, Rukhsana Satarataratar, Syed Ismail Ahmed, Mohammed Oves , Shakeel Ahmed Ansari, and Sandesh Chibber (2019). Utilization of Doped Nanoparticles of ZnO and TiO2 As Antimicrobial Agent. Orient J Chem;35(3). (IF: 0.5).                                       
   19. Ashraf M. Essa, Khaled E. El-Gayar, Mohamed N. Awad, Majed Al-Shaeri, Mohamed Abdel Salam, and Hassien M. Alnashiri (2019). Bacterial purification of sewage wastewater effluents and its influence on germination indices of Vigna radiata and Hordeum vulgare. Polish Journal of Environmental Studies, 28(5). (IF: 1.77).                                                     
   20. Sabir, Jamal SM, Abdelfatteh El Omri, Noor A. Shaik, Babajan Banaganapalli, Majed A. Al-Shaeri, Naser A. Alkenani, Nahid H. Hajrah et al. (2019): "Identification of key regulatory genes connected to NF-κB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network." PloS one 14, no. 4 :e0214337. (IF: 3.24).                        
   21. Ali, Khursheed, Bilal Ahmed, Sabiha M. Ansari, Quaiser Saquib, Abdulaziz A. Al-Khedhairy, Sourabh Dwivedi, Majed Alshaeri, Mohd Saghir Khan, and Javed Musarrat (2019) "Comparative in situ ROS mediated killing of bacteria with bulk analogue, Eucalyptus leaf extract (ELE)-capped and bare surface copper oxide nanoparticles." Materials Science and Engineering: C. (IF: 7.328).                                                                      
   22. Bilal Ahmed, Sourabh Dwivedi, Malik Zainul Abdin, Ameer Azam, Majed Al-Shaeri, Mohammad Khan, Quaiser Saquib, Abdulaziz Al-Khedhairy & Javed Musarrat. (2017) Mitochondrial and Chromosomal Damage Induced by Oxidative Stress in Zn2+ Ions, ZnO-Bulk and ZnO-NPs treated Allium cepa roots. Scientific reports. (IF: 4.525).
   23. Samia Saleem, Bilal Ahmed, Mohammad Saghir Khan, Majed Al-Shaeri, Javed Musarrat (2017) Inhibition of growth and biofilm formation of clinical bacterial isolates by NiO nanoparticles synthesized from Eucalyptus globulus plants." Microbial pathogenesis 111: 375-387. (IF: 3.738).
   24. Khursheed Ali, Faizan Abul Qais, Sourabh Dwivedi, Eslam M Abdel-Salam, Sabiha M Ansari, Quaiser Saquib, Mohammad Faisal, Abdulaziz A Al-Khedhairy, Majed Al-Shaeri, Javed Musarrat (2017) Titanium dioxide nanoparticles preferentially bind in subdomains IB, IIA of HSA and minor groove of DNA. Journal of Biomolecular Structure and Dynamics. Jul 28:1-40. doi: 10.1080/07391102.2017.1361339. [Epub ahead of print] PMID: 28753123, Taylor & Francis. (IF: 3.12).               
   25. Miller, M., Bankier, C., Al-Shaeri, M., Ahmed, Hartl, M. G.J. (2015) Neutral Red Retention assay for assessing carbon nanotube ecotoxicity - comparing microscope and microplate methods. Marine Pollution Bulletin. (IF: 3.09)
   26. Al-Shaeri, M., Ahmed, D., Mc Cluskey, F., Turner, G., Paterson, L., Dyrynda, E. A. & Hartl, M. G. J. (2013). “Potentiating toxicological interaction of single-walled carbon nanotubes with dissolved metals”. Environ. Toxicol. Chem. 32: 2701-271. (IF: 3.179).

Selected of Conference Posters & Presentations

Al-Shaeri, M., Ahmed, Cyphus, P., Paterson, L. & Mark G J Hartl. (2011) “Ecotoxicological implications of the interactions between single-walled carbon nanotubes with metals”. 6th International Conference on the Environmental Effects of Nanoparticles and Nanomaterials. London 19th-21st September.

Al-Shaeri, M., Ahmed, Paterson, L., Cyphus, P. & Mark G J Hartl. (2013) “Impact of agglomerated single walled carbon nanotubes on marine green algae Tetraselmis suecica”. 23rd SETAC Europe Annual Meeting in Glasgow, United Kingdom.

Al-Shaeri, M., Ahmed, Stobie, M., Cyphus, P., Paterson, L. & Mark G J Hartl. (2014) “Green algae interacting with single-walled carbon nanotubes affect the feeding behaviour of mussels, mitigating nanotube toxicity”. SETAC Europe Annual Meeting in Basel, Switzerland.

Al-Shaeri, M., Ahmed, D., Mc Cluskey, F., Turner, G., Paterson, L., Dyrynda, E. A. & Hartl, M. G. J. (2013). “Potentiating toxicological interaction of single-walled carbon nanotubes with dissolved metals”. Marine Alliance for Science and Technology for Scotland (MASTS) in Edinburgh, United Kingdom.